Answer Explanations 4
The differences in response to similar chemicals can only be approximated and should not be extrapolated if human exposure is expected. For instance, 1,3-D can be genotoxic but is mostly detoxified via GSH. However, there will always be a ratio of detoxification to toxic escape of reactive species. This ratio may change with chemical structure of the compound.
I think that there are enough 1,3-D 2 year carcinogenesis studies in rats and mice , and it is not necessary to rely upon cancer bioassay data for structurally similar chemicals.
In my opinion, we have an adequate database to assess the potential carcinogenicity of 1,3-D.
sufficient data available for 1,3-D, structurally similar chemicals may not undergo identical biotransformation reactions and thus any conclusion may be highly uncertain