SciPi 145: Peer review of the genotoxicity, toxicokinetics, and carcinogenicity of a pesticide
Given the number of cancer studies available for 1,3-D, is there a need to rely upon cancer bioassay data for structurally similar chemicals?
Results
(4 Answers)
Answer Explanations
- NoExpert 11
sufficient data available for 1,3-D, structurally similar chemicals may not undergo identical biotransformation reactions and thus any conclusion may be highly uncertain
- NoExpert 6
I think that there are enough 1,3-D 2 year carcinogenesis studies in rats and mice , and it is not necessary to rely upon cancer bioassay data for structurally similar chemicals.
- NoExpert 5
The differences in response to similar chemicals can only be approximated and should not be extrapolated if human exposure is expected. For instance, 1,3-D can be genotoxic but is mostly detoxified via GSH. However, there will always be a ratio of detoxification to toxic escape of reactive species. This ratio may change with chemical structure of the compound.
- NoExpert 9
In my opinion, we have an adequate database to assess the potential carcinogenicity of 1,3-D.
Expert 11
04/18/2019 02:31Looks like agreement, I would not add the NTP studies to an evaluation due to presence of epichlorohydrin and potentially other contaminants ?
Expert 6
04/22/2019 17:33Yes, not add the NTP studies due to the presence of epichlorohydrin in Telone II used for that study.
Expert 2
04/24/2019 08:06There are contrary views throughout this survey as to the ability of a 1% epichlorohydrin impurity to explain away ALL the positive findings in the NTP bioassays.