One of the important differences between in vitro and in vivo studies is the availability of detoxification pathways such as glutathione conjugation. The role of glutathione on genotoxicity of 1,3-D was explicitly assessed (Lawlor, 2004). Do you agree that glutathione is protective of 1,3-D genotoxicity?

Answer Explanations

• Yes

  Expert 1

  Yes, this is helpful evidence but not completely adressing all open questions

• Yes

  Expert 14

  Yes, the protective role of glutathione on the 1,3 D genotoxicity has been shown in bacteria (Lawlor 2004) and in mammalian cells (Brooks, 1991).

• Yes

  Expert 5

  The direct answer to this question is yes, but this does not mean it is completely effective in all organs.