Answer Explanations 3
Can be considered, yes, but I don't think that for a data rich compound (with some controversial findings) as is the case here data from structural analogs would add much to the discussion
It’s hard to think of a good surrogate. 1,3-D is such a small molecule that almost any change will likely alter its reactivity substantially. Substitution at the CH2 would likely be the most conservative. I found a couple of refs to 1,3,3-TC-propene. It was inactive in MN assay, in vivo and in vitro, but produced strand breaks in vitro. This doesn't really add much to considerations about 1,3-D and I don’t think any other structural surrogate would add anything useful.
Structurally related aloalkenes (e.g. vinyl bromide) are genotoxic and carcinogenic.