Answer Explanations 3
Other than strand breakage assays, I see no evidence that 1,3-D is genotoxic in vivo. The strand break assays used doses well above the kinetically-derived maximum dose, likely indicating their mechanisms of action were not relevant to human exposure conditions. However, full dose responses were not carried out, so results at exposure-relevant doses are unknown. In a weight of evidence approach, these considerations lead me to conclude with a fairly high degree of confidence the 1,3-D is not genotoxic to humans at realistic exposure conditions. However, additional state-of-the art assays that show negative results would increase my confidence.
Clastogenicity and aneugenicity are not fully covered neither in vitro nor in vivo, due to the limitations/shortcomings of the data set available.
some calls were made in absence of original data, confidence would be higher with all data available, historical background ranges, etc.