Answer Explanations 3
Most likely mutagenicExpert 5
Watson paper, Chem Bio Interactions, 1987 is most relevant as the 1,3-D was purified. I believe a strict answer to the above question is that 1,3-D has some mutagenic potential. However, based on the low yield its metabolism to the epoxide, and its detoxification by glutathione, I do not think it poses a mutagenic threat in vivo.
Most likely NOT mutagenicExpert 14
This view is based on the fact that the mutagenic concern coming from the positive findings in the Ames test is ruled out by clear negative results in appropriate in vivo follow-up studies.
Clearly NOT mutagenicExpert 1
Clean, state-of-the art in vivo mutagenicity data available. Only potential vulnerability as mentioned earlier may be the selection of the top dose (could probably be better explained)