Answer Explanations 3
Yes it affects my conclusions. I think the lack of a consistent dose response and positive results nearly always only that highest dose, are not what I would expect from a genotoxic agent.
I cannot answerExpert 14
In my opinion, genotoxicity should be thoroughly and deeply investigated with the appropriate in vitro and in vivo test batteries for hazard identification regardless of cancer bioassay information. In addition, the implication of mutations are not limited to cancer but involve genetic diseases and somatic illnesses.
The pattern does not speak for a genotoxic carcinogen (usually multi-tissue tunors). In line with negative result for gene mutation