Six cancer bioassays (4 by oral route; 2 by inhalation) have been conducted for 1,3D with the following pattern of results: 1) 4/6 bioassays reported negative results; 2) 1 oral bioassay showed increased benign liver tumors with a P>0.01 in one sex and high dose only; and 3) 1 inhalation bioassay reported increased benign lung tumors in one sex at a high concentration (exceeding metabolic saturation). Does this pattern of tumor results affect your conclusions on the mutagenic/genotoxic potential of 1,3-D, and if so how?

Answer Explanations

• Yes

  Expert 1

  The pattern does not speak for a genotoxic carcinogen (usually multi-tissue tunors). In line with negative result for gene mutation

• I cannot answer

  Expert 14

  In my opinion, genotoxicity should be thoroughly and deeply investigated with the appropriate in vitro and in vivo test batteries for hazard identification regardless of cancer bioassay information. In addition, the implication of mutations are not limited to cancer but involve genetic diseases and somatic illnesses.

• Yes

  Expert 5

  Yes it affects my conclusions. I think the lack of a consistent dose response and positive results nearly always only that highest dose, are not what I would expect from a genotoxic agent.